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The adjuvant of canarypox-protein HIV-Vaccine (ALVAC-HIV) plus bivalent subtype C gp120-MF59, according to a report published on 25 March in the New England Journal of Medicine, does not avoid HIV-1 infection among adults in South Africa. In a phase 2b-3 trial in South Africa, 5,404 adults without an HIV-2 infection have been allocated to the canarypox protein HIV vaccine or placebo for the Fred Hutchinson Cancer Research Center in Seattle as well as for colleagues without an HIV-1 infection (2,704 and 2,700 participants, respectively). ALVAC/HIV injected was taken at months 0 and 1, followed by adjuvant boosters at months 3, 6, 12 and 18 with ALVAC-HIV injecting plus bivalent subtype C gp120-MF59.
According to researchers, the provisional review reached prescribed non-efficacy requirements in January 2020 and subsequently stopped further vaccinations. Both the vaccine and placebo groups had a similar adverse reaction rate. In 138 and 133 students of the vaccine and placebo classes respectively, during the 24-month follow-up HIV-1, infection was observing (hazard ratio, 1.02; 95% confidence interval, 0.81 to 1.30; P = 0.84).
The authors write that "This canarypox-protein HIV vaccine scheme has failed to prevent HIV-1 in our South African trial population, despite its promising immunogenicity." "The high incidence of HIV-1 that we saw in our study shows an unstoppable epidemic, particularly among young women."
The research was sponsored by Novartis Vaccines and diagnostics now part of GlaxoSmithK line Biologicals and contributed to the pre-exposure prophylaxis of the study participants financially as well.
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Content created and supplied by: Health360 (via Opera News )