Cristiano Ronaldo, Raphael Varane, Edinson Cavani, and Luke Shaw were not among the 21 Manchester United players who stayed at the Lowry Hotel ahead of their Premier League match against Manchester City.
This could imply that the Portuguese star would miss the Manchester derby against Pep Guardiola's team, according to many foreign media agencies, including the famed La Gazzetta dello Sport.
The Manchester Evening News, a British publication, reports that the Red Devils are likely to be without Ronaldo.
Cavani, Varane, and Shaw are all absent, in addition to Ronaldo. The Uruguayan is coming off a groin issue, but coach Ralf Rangnick deemed him fit for the Etihad Stadium match, which is slated for 5.30pm local time.
Cristiano Ronaldo, the Manchester United forward, has been ruled out of the club's local derby this afternoon.
Edinson Cavani is also not expected to be included in the matchday squad, leaving Ralf Rangnick's side short on attacking alternatives.
Due to a paucity of options, Marcus Rashford is set to play down the middle until United manager Jose Mourinho opts for him as a false nine.
With 15 goals in 30 appearances in all competitions this season, the 37-year-old is United's highest scorer.
Only one of those objectives was met in 2022. Ronaldo has only scored once in his past ten games, a well-taken long-range goal in a 2-0 home win over Brighton & Hove Albion on February 15.
With both Ronaldo and Cavani absent, Rashford will be handed the opportunity to shine through the middle, according to.
Rangnick stated that the 24-year-old has "rich talent" despite the fact that the England international has not scored since a 1-0 win over West Ham United on January 22.
With Marcus Rashford, we have yet another youngster on whom I will insist on putting my whole support in order to help him develop. We've done it with a number of young players in the past, and I don't see why Marcus can't do the same.
'He's got a lot of potential, he's got pace, he's got physicality, he's got everything you need as a contemporary striker, whether he's playing on the wing or in the middle.'
'I'll devote all of my efforts to ensuring that he follows in the footsteps of other players in recent months.'
United may also be missing Raphael Varane, a £34 million summer acquisition, and England left defender Luke Shaw.
The Red Devils are still in fourth place in the Premier League, but Arsenal are only two points behind them with three games to go.
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