The GPL took a break last weekend to make way for the semi-final matches in the MTN FA Cup competition.
Leaders Asante Kotoko will look to continue with their quest of winning the title when they trek to Obuasi to face troubled AshantiGold SC at the Len Can Stadium on Thursday.
Also on Thursday, Legon Cities will host Dreams FC at the El-Wak Military Sports Stadium in Accra.
The midweek action will begin on Wednesday afternoon when reigning champions Accra Hearts of Oak hosts Bibiani Gold Stars at the Accra Sports Stadium.
Berekum Chelsea will welcome Medeama SC to the Golden City Park in Berekum where they have been very formidable at this season.
King Faisal Babes will look for some respite when they host Techiman Eleven Wonders at the Baba Yara Stadium in Kumasi in a relegation battle between the two sides.
WAFA will be home to Accra Lions at the Red Bull Arena at Sogakope where they will need the three points to aid in their survival hopes.
Aduana FC will be clear favourites to collect the three points when they host bottom side Elmina Sharks at the Nana Agyeman Badu I Park at Dormaa Ahenkro.
Karela United will host Accra Great Olympics at the Crosbby Awuah Memorial, (CAM) Park at Anyinase in the Western region of Ghana.
Relegation strugglers Real Tamale United, RTU will welcome second placed Bechem United to the Aliu Mahama Sports Stadium in Tamale in a game they will look for the three points to help their own as they seek to avoid the drop.
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