The home side appreciated early belonging however it was the guests who had the previously shot on track after Mexican-based midfielder Luis Leal Dos Anjos discharged a long-range freekick that went inches wide.
Ajax pro Mohammed Kudus' splendid corner was impeccably met noticeable all around by safeguard Nicholas Opoku for the opener following 12 minutes.
São Tomé was constrained into an early replacement after Rosa Cardosa was supplanted by Pires di Mata following a physical issue he picked.
Minutes after the fact Mohammed Kudus sent in another splendid pass to Jordan Ayew who was fouled in the case for a punishment. The Crystal Palace man tranquilly positioned it in the extreme right corner with the goalkeeper moving the alternate way.
Only a couple minutes to halftime, Kudus Mohammed constrained a save from the São Tomé goalie subsequent to taking on a protector and releasing a shot.
Mentor C.K Akonnor rolled out a snappy improvement at halftime, welcoming on Gladson Awako for Osman Bukari as the Ghanaian group keep on ruling.
Mubarak Wakaso verged on making it three with a long-range drive, before Baba Rahman sent in a pass on the left which almost discovered Kudus yet for the mediation of a São Tomé protector.
The subsequent corner saw Kudus rankle his way into the crate to discover Rahman who terminated home the third on the hour mark.
The gaffer at that point rolled out two speedy improvements, supplanting the goalscorers Rahman and Jordan with Ibrahim Imoro and Kwesi Okyere Wriedt separately.
An error by goalkeeper Razak Abalora in the wake of getting a back pass from Imoro saw the guests get one back through Fernandez Calvaho.
Kwesi Wreidt almost put forth it four yet his attempt from fresh went barely wide.
Equity Blay supplanted Wakaso with the clock ticking down, and Wriedt saw a last moment exertion saved followed by an Andre Ayew strike which was hindered.
Ghana completed the gathering top of the table with 13 focuses.
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