Arch rivals in the league, this encounter tends to be a tough test of the season as both sides are not pretty settled given their last two games.
Asante Kotoko lost bitterly in the CAF Champions League on penalties shoot-out to Burkinabe side RC Kadiogo in the second leg after getting the head start as visitors courtesy of Isaac Oppong.
Likewise, Hearts of Oak - two games in the Premier League without a win - lost to Aduana Stars in the opening game and drew at Great Olympics.
Following this, the two sides will look to redeem themselves which makes this clash dicey.
Injury concerns - the Porcupine Warriors will miss the services of Justice Blay and Sheriff Mohammed.
Also, the club's top-scorer last season - Franck Etouga Mbella who left for Egyptian side Al Masry SC days ago.
With the Phobians - Abdul Aziz Nurudeen and Amankwah Baafi alongside new signees, Prince Nana Kwasi Darmang and Congolese international Linda Mtange due to ITC issues.
Probable Starting Lineup
Kotoko: Ibrahim Danlad, Christopher Nettey, John Tedeku, Yussif Mubarik, Sheriff Mohammed, Richard Boadu, Enock Morrison, George Mfegue, Isaac Oppong, Samuel Boateng, Steven Mukwala.
Hearts of Oak: Eric Ofori Antwi, Samuel Inkoom, Dennis Korsah, Mohammed Alhassan, Konadu Yiadom, Eric Esso, Gladson Awako, Ibrahim Salifu, Suraj Seidu, Kwadwo Obeng Jr., Isaac Mensah.
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