Amartey was only able to join the Black Stars for the game against Ethiopia at Cape Coast, thanks to the FA Cup winners.
The Foxes, like the rest of the Premier League's 19 clubs, have banned players from visiting countries on the COVID-19 red list.
This means that South Africa, which is a red zone on the FA's list, is a no-go zone for English players.
Amartey will be compelled to quarantine for 10 days if he travels to South Africa, and he will miss three games, including a Europa League encounter.
After appearing in all three games for Leicester this season, Daniel Amartey is having one of his greatest seasons in England.
The Ghanaian will be required by manager Brendan Rogers for the matches against Manchester City, Napoli, and Brighton & Hove Albion.
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