Subsequent to blasting over the bar in the main half, Mane played a flawless one-two preceding jabbing home not long before the hour as the Liverpool star opened the scoring.
While Mane is allowed to play since his two matches are in nations that are not on the British government's Covid red rundown, club partner Mohamed Salah couldn't play at home to Angola on Wednesday as Egypt is on the rundown.
Unburdened by the danger of isolating for 10 days upon his re-visitation of England, Mane was vivacious all through in a game wrapped up when Abdou Diallo lashed home following a corner a short ways from time.
The triumph addresses a pinch of retribution for the Senegalese, who couldn't beat Togo as the Sparrowhawks pipped them to the 2006 World Cup when they last met at this stage.
Senegal travel to Congo on Tuesday, while Togo look for their first focuses at home to Namibia on Sunday.
Without their star man in a void yet huge Cairo field, Egypt needed to depend on a fifth-minute punishment from Mohamed Magdy Morsy against a bustling Angolan side who battled as far as possible.
The guests will lament botched opportunities and a vain punishment guarantee as they neglected to exploit the eminent shortfall of Salah, who could play in Gabon one week from now.
While the Pharaohs' place at the highest point of Group F might be little amazement, that of Libya is nevertheless the North Africans acquired a much-relished 2-1 win against Gabon on the plastic pitch of Benghazi.
The guests drove ahead of schedule through Andre Biyogo Poko just for Libya to react through Ali Alamami close to the half hour before Sand Masaud got a sensational last-minute victor.
The success was planned by Javier Clemente who returned recently to a job he served between 2013-2016, during which he won Libya's first African title.
Somewhere else, it finished 1-1 as neighbors Guinea-Bissau and Guinea met in a World Cup qualifier without precedent for a very long time.
The game ought to have been played in Bissau yet as the arena there was considered unsuitable by the Confederation of African Football (Caf) last month, it occurred in Mauritania.
An accessible Liverpool player was again in the main part of the activity as Naby Keita - accessible for both Guinea's games - teed up Francois Kamano for the opener before Joseph Mendes procured the two sides a point in Group I.
Sadio Mane set Senegal on their way against Togo on Wednesday
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